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This observational, cross sectional study was conducted from July 2011 to September 2012 in the department of Gastroenterology, BSMMU, Dhaka, Bangladesh. Study group comprised of 204 patients of chronic liver disease. In the study it was observable that CLD due to viral etiology was the most common cause (89%) of cirrhosis followed by cryptogenic (11%). Coarse liver echotexture was found in 100% patients on USG. Upper GI endoscopy revealed esophageal varices in 100% patients of all group except viral etiology (86.5%). Out of all patients only 17.6% patient’s presenting feature were variceal bleeding, with highest incidence in viral etiology, and 84.3% patients of viral etiology had decompensation at presentation. Child-Pugh B and C were more common in all groups. Regarding the CLDQ score in different domain, abdominal symptoms, fatigue and emotional function were statistically significant but systemic symptoms, activity and worry were not statistically significant. In all domain, patients with Child-Pugh stage A score highest followed by Child-Pugh stage B score then Child-Pugh stage C score. Presence of ascites significantly impaired the quality of life of patients with cirrhosis as compared to those without. Child-Pugh C status was associated with lower CLDQ scores thus poorer quality of life.