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Deep vein thrombosis is a common disease entity to which attention should be paid due to its complication of pulmonary embolism. This disease usually has precipitating factors such as obesity, varicose veins or non-ambulation. Congenital coagulation defects should be suspected if patient has recurrent deep vein thrombosis without identifiable precipitating factors. We report a case of 34-year-old male, who had two events of deep vein thrombosis within four months. Doppler ultrasound study at the time of the first event showed thrombosis of popliteal and anterior tibial veins. Coagulation factors study revealed that patient had Lupus anticoagulant positive. In patients with recurrent deep vein thrombosis, hereditary and auto-immune mediated coagulation defect should be suspected and warfarin should be used indefinitely.